Aluminium (Al) is the most abundant metal known for its neurotoxicity in humans…. It has been reported to be involved in the etiology of several neurodegenerative diseases. In this study, we have investigated the effects of long-term intake of aluminium chloride (AlCl(3)) on the electrophysiological, behavioral, biochemical and histochemical functions of hippocampus…. In conclusion, the…

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Aluminum (Al) is present in the daily life of humans, and the incidence of Al contamination increased in recent years. Long-term excessive Al intake induces neuroinflammation and cognition impairment…. These results showed exposure to AlCl3 lead to increased mRNA levels of IL-1β, IL-6, TNF-α and MCH II, decreased mRNA levels of CX3CL1 and BDNF, decreased…

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Long Evans rats were treated for 90 days with water-soluble, insoluble or chelated aluminium compounds…. Acetylcholinesterase activity increased and choline-acetyltransferase activity decreased, resulting in a diminished cholinergic activity, which is a characteristic of Alzheimer’s disease. Abstract. Food and chemical toxicology: An International journal published for the British Industrial Biological Research Association 1993; 31(5):357-61

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Curcumin is a polyphenol extracted from the rhizome of Curcuma longa and well known as a multi-functional drug with antioxidative, anti-cancerous and anti-inflammatory activities…. Our results indicate that curcumin’s ability to bind redox active metals and cross the blood-brain barrier could be playing crucial role in preventing against Al-induced neurotoxicity. Abstract. Pharmacology, biochemistry, and behavior…

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No abstract available Clinical Trial. JAMA pediatrics 2013; 167(9):870-2

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Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic encephalomyelitis/chronic fatigue/syndrome…. Brain translocation of alum particles is linked to a Trojan horse…

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Aluminium hydroxide (AH) and aluminium phosphate (AP) adjuvants, labelled with 26Al, were injected intramuscularly (i.m.) in New Zealand White rabbits…. This study has demonstrated that in vivo mechanisms are available to eliminate aluminium-containing adjuvants after i.m. administration. In addition, the pharmacokinetic profiles of AH and AP adjuvants are different. Vaccine; 15(12-13):1314-8

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Some vaccines contain aluminum adjuvants to enhance the immunological response, and it has been postulated that this aluminum could contribute to adverse health effects, especially in children who receive a vaccination series starting at birth. The pharmacokinetic properties and end-point toxicities of aluminum are presented. In assessing the relevance of dietary and medical aluminum exposure…

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Aluminum is a ubiquitous element that is released naturally into the environment via volcanic activity and the breakdown of rocks on the earth’s surface. Exposure of the general population to aluminum occurs primarily through the consumption of food, antacids, and buffered analgesics. Exposure to aluminum in the general population can also occur through vaccination, since…

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It is well established that aluminium is toxic at the cellular level and that pathological symptoms follow its entry into organisms (plants, fish, humans) when the normal exclusion mechanisms fail or are bypassed, as for example in renal dialysis…. The observed effects of silicon deficiency can be attributed to consequential aluminium availability. There are important…

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