Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction
Dysregulated cytokine expression and signaling are major contributors to a number of autoimmune diseases…. Because this mechanism also enhanced experimental autoimmune encephalomyelitis (EAE) in wild-type mice, it may be a general etiologic process underlying other Th17 cell-mediated autoimmune diseases. Abstract. Immunity 2008; 29(4):628-36
Read MoreIncreased production of IL-17 in children with autism spectrum disorders and co-morbid asthma
Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD)…. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls. Abstract. Journal of neuroimmunology 2015; 286():33-41
Read MoreElevated serum levels of interleukin-17A in children with autism
The T-helper (Th)1/Th2 dichotomy dominated the field of immune regulation until interleukin (IL)-17-expressing T cells (Th17) were proposed to be a third lineage of helper T cells, the key players in the pathogenesis of autoimmune disorders. Autoimmunity to brain tissue may play a pathogenic role in autism…. This is the first study to measure levels…
Read MoreThe maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring.
Viral infection during pregnancy has been correlated with increased frequency of autism spectrum disorder (ASD) in offspring…. Our data suggest that therapeutic targeting of TH17 cells in susceptible pregnant mothers may reduce the likelihood of bearing children with inflammation-induced ASD-like phenotypes. Abstract. Science (New York, N.Y.) 2016; 351(6276):933-9
Read MoreRegulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration.
Experimental studies suggest that cytokine production may be triggered by seizure activity. Here we determined the levels of interleukin-6 (IL-6) and its soluble receptor components (sIL-6R and sGp130) in CSF and serum from control subjects and patients after different types of seizures…. These results provide further support for a hypothesis of cytokine production induced by…
Read MoreInterleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures.
We have previously reported increased concentrations of interleukin (1L)-6 in CSF from patients with tonic-clonic seizures, where increased cytokine production most likely is a consequence of neuronal epileptic activity associated with seizures…. Our study shows that cytokine network is activated in patients after recent tonic-clonic seizures. We provide evidence of intrathecal production of IL-6 associated…
Read MoreCerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation.
In inflammatory diseases occurring outside the CNS, communication between the periphery and the brain via humoral and/or neural routes results in central neural changes and associated behavioral alterations. We have recently identified another immune-to-CNS communication pathway in the setting of organ-centered peripheral inflammation: namely, the entrance of immune cells into the brain. In our current…
Read MoreNeuroprotective Effect of Nanodiamond in Alzheimer’s Disease Rat Model: a Pivotal Role for Modulating NF-?B and STAT3 Signaling.
Current therapeutic approaches of Alzheimer’s disease (AD) are symptomatic and of modest efficacy, and there is no available effective cure or prevention of AD; hence, the need arise to search for neuroprotective agents to combat AD…. These findings indicate the protective effect of ND against memory deficits and AD-like pathological aberrations probably via modulating NF-kB…
Read MoreSerum and CSF levels of cytokines in acute encephalopathy following prolonged febrile seizures.
It is well known that an acute encephalopathy occasionally follows prolonged febrile seizures. We measured the concentrations of interferon-gamma, tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and soluble TNF receptor 1 (sTNFR1) in serum and CSF during the acute stage in 13 children with acute encephalopathy following prolonged febrile seizures (AEPFS) and 23…
Read MoreRisk of febrile seizures after first dose of measles-mumps-rubella-varicella vaccine: a population-based cohort study.
The combination measles-mumps-rubella-varicella (MMRV) vaccine currently used in Canada (Priorix-Tetra) may increase the risk of febrile seizures relative to the separate vaccines (MMR and varicella) previously administered…. Despite an increased risk of febrile seizures following MMRV (compared with MMR+V), the absolute level of risk was small. Policy-makers need to balance these findings with the potential…
Read More