Influenza Vaccines Time for a Rethink

Officials and professional societies treat influenza as a major public health threat for which the annual vaccine offers a safe and effective solution…. I argue that decisions surrounding influenza vaccines need to include a discussion of these risks and benefits. Abstract. JAMA internal medicine 2013; 173(11):1014-6

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Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine

We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo…. Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses. Abstract. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20

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Annual Vaccination against Influenza Virus Hampers Development of Virus-Specific CD8 T Cell Immunity in Children

Infection with seasonal influenza A viruses induces immunity to potentially pandemic influenza A viruses of other subtypes (heterosubtypic immunity)…. Our results indicate that annual influenza vaccination is effective against seasonal influenza but hampers the development of virus-specific CD8(+) T cell responses. The consequences of these findings are discussed in the light of the development of…

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Vaccination against Human Influenza A:H3N2 Virus Prevents the Induction of Heterosubtypic Immunity against Lethal Infection with Avian Influenza A:H5N1 Virus

Annual vaccination against seasonal influenza viruses is recommended for certain individuals that have a high risk for complications resulting from infection with these viruses…. The lack of protection correlated with reduced virus-specific CD8+ T cell responses after A/H5N1 virus challenge infection. These findings may have implications for the general recommendation to vaccinate all healthy children…

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