Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice.

Maternal immune activation (MIA) results in the development of autism in the offspring via hyperactivation of IL-6 signaling…. We conclude that complex and not necessarily agonistic relationships exist between epileptic and autism-like phenotypes in an animal model of MIA coupled with KA-induced epilepsy and that the nature of these relationships depends on components of MIA involved.

Abstract. Epilepsy & behavior : E&B 2015; 50():40-5