Latest Articles
Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
People with neurodevelopmental disorders and intellectual disabilities have much greater health care needs. The Vitamin D Task Force of the American Academy of Developmental Medicine...
Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring
Experimentally activating the maternal immune system during pregnancy in rodents produces offspring with abnormal brain and behavioral development.... Results extended the findings in rodent MIA...
Maternal Immune Activation in Nonhuman Primates Alters Social Attention in Juvenile Offspring
Sickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders.... The use of noninvasive eye tracking extends the findings from rodent MIA...
The combined role of serotonin and interleukin-6 as biomarker for autism
Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors.... The results of receiver operating characteristic (ROC) analysis indicated that...
Maternal immune activation and abnormal brain development across CNS disorders
Epidemiological studies have shown a clear association between maternal infection and schizophrenia or autism in the progeny. Animal models have revealed maternal immune activation (mIA)...
Cytokines and CNS Development
Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the...
Brain IL-6 and autism
Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and repetitive behavior and restricted interests.... Findings...
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Schizophrenia and autism are thought to result from the interaction between a susceptibility genotype and environmental risk factors.... The identification of IL-6 as a key...
Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway
An emerging area of research in autism spectrum disorder (ASD) is the role of prenatal exposure to inflammatory mediators during critical developmental periods. Epidemiological data...
IL-6 is Increased in the Cerebellum of Autistic Brain and Alters Neural Cell Adhesion, Migration and Synaptic Formation
Although the cellular mechanisms responsible for the pathogenesis of autism are not understood, a growing number of studies have suggested that localized inflammation of the...