Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line
Aluminium-based adjuvants (ABA) are the predominant adjuvants used in human vaccinations. While a consensus is yet to be reached on the aetiology of the biological activities of ABA several studies have identified shape, crystallinity and size as critical factors affecting their adjuvanticity…. Use of these new methods revealed that particulate ABA was only found in…
Read MoreMacrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle
Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff’s reagent-positive macrophages and lymphocytes. Intracytoplasmic inclusions have been observed in macrophages of some patients…. We conclude that the MMF lesion is secondary to intramuscular injection of aluminium hydroxide-containing…
Read MoreDelivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse
As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse…. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer. Abstract. Cancer nanotechnology 2012; 3(1-6):47-54
Read MoreSilicon reduces aluminum accumulation in rats Relevance to the aluminum hypothesis of Alzheimer disease
In recent years, a possible relation between the aluminum and silicon levels in drinking water and the risk of Alzheimer disease (AD) has been established…. The present study was undertaken to examine the influence of supplementing silicon in the diet to prevent tissue aluminum retention in rats exposed to oral aluminum…. The current results corroborate…
Read MoreEffects of vitamin E against aluminum neurotoxicity in rats
The present study examined the protective effects of vitamin E against aluminum-induced neurotoxicity in rats…. Vitamin E treatment reduced the contents of glial markers and cytokines and the levels of LPO. In conclusion, this study demonstrates that vitamin E ameliorates glial activation and reduces release of proinflammatory cytokines induced by aluminum. Abstract. Biochemistry. Biokhimii?a 2006;…
Read MoreAvoidance of aluminum toxicity in freshwater snails involves intracellular silicon-aluminum biointeraction
Silicon (Si) ameliorates aluminum (Al) toxicity to a range of organisms, but in almost all cases this is due to ex vivo Si-Al interactions forming inert hydroxyaluminosilicates (HAS). We hypothesized a Si-specific intracellular mechanism for Al detoxification in aquatic snails, involving regulation of orthosilicic acid [Si(OH)4]…. Given the environmental abundance of both elements, we anticipate…
Read MoreDelivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse
As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse…. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer. Abstract. Cancer nanotechnology 2012; 3(1-6):47-54
Read MoreAluminum vaccine adjuvants: are they safe?
Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. …Experimental research shows aluminum adjuvants have a potential to induce serious immunological disorders in humans…. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the…
Read MoreAluminum hydroxide injections lead to motor deficits and motor neuron degeneration
Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990-1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable from classical amyotrophic lateral sclerosis (ALS) except for the age of onset…. Aluminum-treated mice showed…
Read MoreAdministration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes
Our previous ecological studies of autism spectrum disorder (ASD) has demonstrated a correlation between increasing ASD rates and aluminium (Al) adjuvants in common use in paediatric vaccines in several Western countries. The correlation between ASD rate and Al adjuvant amounts appears to be dose-dependent and satisfies 8 of 9 Hill criteria for causality…. These current…
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