Slow CCL2-dependent translocation of biopersistent particles from muscle to brain
Long-term biodistribution of nanomaterials used in medicine is largely unknown…. Although generally well tolerated, alum is occasionally detected within monocyte-lineage cells long after immunization in presumably susceptible individuals with systemic/neurologic manifestations or autoimmune (inflammatory) syndrome induced by adjuvants (ASIA). Nanomaterials can be transported by monocyte-lineage cells to DLNs, blood and spleen, and, similarly to HIV,…
Read MoreAddressing Parents’ Concerns: Do Vaccines Contain Harmful Preservatives, Adjuvants, Additives, or Residuals?
Vaccines often contain preservatives, adjuvants, additives, or manufacturing residuals in addition to pathogen-specific immunogens. Some parents, alerted by stories in the news media or information contained on the World Wide Web, are concerned that some of the substances contained in vaccines might harm their children. We reviewed data on thimerosal, aluminum, gelatin, human serum albumin,…
Read MoreMetabolism and Possible Health Effects of Aluminum
Literature regarding the biochemistry of aluminum and eight similar ions is reviewed…. The possibility that Al3+ may cause or contribute to some specific diseases, most of them related to aging, is discussed with the proposed metabolic picture in mind. Abstract. Environmental health perspectives 1986; 65():363-441
Read MoreLead Poisoning in an Adult: Lead Mobilization by Pregnancy?
We report a case of acute lead poisoning in an adult female … with abdominal pain, knee pain, and neurological symptoms, hypertension, chronic kidney disease, and anemia with basophilic stippling and lead gum lines…. This case report illustrates the seriousness of long-term health effects associated with lead poisoning at a multi-organ level, even years after…
Read MoreEffects of Aluminum Ingestion on Spontaneous Motor Activity in Mice
Aluminum (Al) as aluminum lactate in a purified diet was fed to adult female Swiss-Webster mice over a six week period. Comparison groups were: controls (CON), 25 micrograms Al/g diet; low Al (LO), 500 micrograms Al/g diet; high Al (HI), 1000 micrograms Al/g diet; and pair fed (PF) 25 micrograms Al/g diet pair fed to…
Read MoreAluminum Neurotoxicity In Preterm Infants Receiving Intravenous-feeding Solutions
Aluminum, a contaminant of commercial intravenous-feeding solutions, is potentially neurotoxic. We investigated the effect of perinatal exposure to intravenous aluminum on the neurologic development of infants born prematurely…. In preterm infants, prolonged intravenous feeding with solutions containing aluminum is associated with impaired neurologic development. Abstract. N England Journal of Medicine 1997 May 29;336(22):1557-61.
Read MoreAluminum Adjuvant Linked to Gulf War Illness Induces Motor Neuron Death in Mice
Gulf War Illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but itsorigin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders.
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