Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice.
Maternal immune activation (MIA) results in the development of autism in the offspring via hyperactivation of IL-6 signaling…. We conclude that complex and not necessarily agonistic relationships exist between epileptic and autism-like phenotypes in an animal model of MIA coupled with KA-induced epilepsy and that the nature of these relationships depends on components of MIA…
Read MorePreliminary evidence of neuropathology in nonhuman primates prenatally exposed to maternal immune activation.
Brain, behavior, and immunity 2015; 48():139-46 Maternal infection during pregnancy increases the risk for neurodevelopmental disorders in offspring…. The data provide the first evidence that prenatal exposure to MIA alters dendritic morphology in a nonhuman primate MIA model, which may have profound implications for revealing the underlying neuropathology of neurodevelopmental disorders related to maternal infection.…
Read MoreDietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model.
Prenatal exposure to maternal immune activation (MIA) increases the risk of schizophrenia and autism in the offspring…. The main findings were: (i) Adult MIA-exposed mice fed a standard diet had greater N-acetylaspartate/creatine (Cr) and lower myo-inositol/Cr levels in the cingulate cortex in vivo. (ii) The extent of these metabolite differences was correlated with impairment in…
Read MoreMaternal Lipopolysaccharide Exposure Promotes Immunological Functional Changes in Adult Offspring CD4+ T Cells.
Maternal immune activation (MIA) is a risk factor for autism and schizophrenia. However, how MIA affects offspring immune function remains unknown…. Our results showed that MIA to LPS up-regulated proteins involved in metabolic process in CD4+ T cells from LPS offspring that might contribute to the hyperactivated immune response of adult LPS offspring. Abstract. American…
Read MoreWhat is the role of vitamin D in autism?
A growing body of literature suggests that higher serum 25-hydroxyvitamin D [25(OH)D] concentrations, either in utero or in early life, may reduce the risk of autism…. Vitamin D deficiency during pregnancy and childhood is a widespread and growing epidemic. Abstract. Dermato-endocrinology 2013; 5(1):199-204
Read MoreOn the aetiology of autism
Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
People with neurodevelopmental disorders and intellectual disabilities have much greater health care needs. The Vitamin D Task Force of the American Academy of Developmental Medicine and Dentistry (AADMD) reviewed the evidence of 25(OH)D concentrations that benefit the health of persons with developmental disabilities…. The Task Force recommends that 25(OH)D concentrations for optimal health to be…
Read MoreActivation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring
Experimentally activating the maternal immune system during pregnancy in rodents produces offspring with abnormal brain and behavioral development…. Results extended the findings in rodent MIA models to more human-like behaviors resembling those in both autism and schizophrenia. Abstract. Biological psychiatry 2014; 75(4):332-41
Read MoreMaternal Immune Activation in Nonhuman Primates Alters Social Attention in Juvenile Offspring
Sickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders…. The use of noninvasive eye tracking extends the findings from rodent MIA models to more human-like behaviors resembling those in both autism spectrum disorder and schizophrenia. Abstract. Biological psychiatry 2015; 77(9):823-32
Read MoreThe combined role of serotonin and interleukin-6 as biomarker for autism
Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors…. The results of receiver operating characteristic (ROC) analysis indicated that the combination of 5-HT and IL-6 produced the best sensitivity and specificity for diagnosis of autism. Therefore, the present study has revealed a simple clinical method with great potential for…
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