Elevated immune response in the brain of autistic patients.

This study determined immune activities in the brain of ASD patients and matched normal subjects by examining cytokines in the brain tissue…. ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD. Abstract. Journal of…

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Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism

Autism is a neurodevelopmental disorder characterized by impaired communication and social interaction and may be accompanied by mental retardation and epilepsy. Findings indicate that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain. Abstract. Annals of neurology 2005;…

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Gender-Dependent Effects of Maternal Immune Activation on the Behavior of Mouse Offspring

Autism spectrum disorders are neurodevelopmental disorders characterized by two core symptoms; impaired social interactions and communication, and ritualistic or repetitive behaviors. Findings indicate that offspring from mothers subjected to immune stimulation during gestation show a gender-specific increase in stereotyped repetitive behavior. Abstract. PloS one 2014; 9(8):e104433

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Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism

The core symptoms of autism are deficits in social interaction and language, and the presence of repetitive/stereotyped behaviors. The results indicate that MIA yields male offspring with deficient social and communicative behavior, as well as high levels of repetitive behaviors, all of which are hallmarks of autism. Abstract. Behavior and immunity 2012; 26(4):607-16

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