Live vaccines have distinct safety profiles, potentially causing systemic reactions one to 2 weeks after administration…. Future studies should examine whether these events could be predicted or prevented. Abstract. PloS one 2011; 6(12):e27897

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Vaccine administration is the second leading cause of febrile seizures (FS)…. This review discusses the clinical implications of FS, its potential link to vaccinations and its impact on official recommendations for vaccinations in children…. Therefore, post-marketing surveillance studies are required to accurately assess the incidence of FS and identify individuals who are particularly susceptible to…

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Th1-like (IL-2, IFN-gamma) and Th2-like (IL-4, IL-6, and IL-10) cytokines were examined in CD4+ and CD8+ T cells in children with autism…. These data suggest that an imbalance of Th1- and Th2-like cytokines in autism may play a role in the pathogenesis of autism. Abstract. Journal of neuroimmunology 1998; 85(1):106-9

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Maternal infection during pregnancy increases the risk for neurodevelopmental disorders in offspring. Rodent models have played a critical role in establishing maternal immune activation (MIA) as a causal factor for altered brain and behavioral development in offspring…. These data provide the first evidence that prenatal exposure to MIA alters dendritic morphology in a nonhuman primate…

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Immune activation can exert multiple effects on synaptic transmission. Our study demonstrates the influence of neonatal vaccination on hippocampal synaptic plasticity in rats under normal physiological conditions. The results revealed that neonatal BCG vaccination enhanced synaptic plasticity. In contrast, HBV hampered it. Furthermore, we found that the cytokine balance shifted in favour of the T…

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Over the past several decades, significant advances have been made in our understanding of the basic stages and mechanisms of mammalian brain development. Studies elucidating the neurobiology of brain development span the levels of neural organization from the macroanatomic, to the cellular, to the molecular. Together this large body of work provides a picture of…

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Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and disability in infants and children…. We consider the timing of neurogenesis, synaptogenesis, gliogenesis, oligodendrocyte maturation and age-dependent behaviors that coincide with developmentally regulated molecular and biochemical changes…. With a focus on developmental hypoxic-ischemic encephalopathy and traumatic brain injury, this review offers guidelines for…

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We describe a 32-month-old patient with enteroviral encephalitis confirmed by polymerase chain reaction in cerebrospinal fluid, with unfavorable clinical course with marked developmental regression, autistic features, persistent stereotypes and aphasia…. This case report is significant in presenting a case of developmental regression with autistic features and loss of language improving on follow-up. Abstract. Journal of…

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Autism is a childhood onset neurodevelopmental disorder characterized by reciprocal social deficits, communication impairment, and rigid ritualistic interests, with the onset almost always before three years of age…. This case further supports the role of environmental factors, such as infections, in the etiology of autism, and suggests that in a minority of cases, autistic symptoms…

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Journal of autism and developmental disorders 1986; 16(3):369-75 No abstract available

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