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Maternal Immune Activation in Nonhuman Primates Alters Social Attention in Juvenile Offspring
Sickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders.... The use of noninvasive eye tracking extends the findings from rodent MIA...
The combined role of serotonin and interleukin-6 as biomarker for autism
Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors.... The results of receiver operating characteristic (ROC) analysis indicated that...
Maternal immune activation and abnormal brain development across CNS disorders
Epidemiological studies have shown a clear association between maternal infection and schizophrenia or autism in the progeny. Animal models have revealed maternal immune activation (mIA)...
Cytokines and CNS Development
Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the...
Brain IL-6 and autism
Autism is a severe neurodevelopmental disorder characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and repetitive behavior and restricted interests.... Findings...
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Schizophrenia and autism are thought to result from the interaction between a susceptibility genotype and environmental risk factors.... The identification of IL-6 as a key...
Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway
An emerging area of research in autism spectrum disorder (ASD) is the role of prenatal exposure to inflammatory mediators during critical developmental periods. Epidemiological data...
IL-6 is Increased in the Cerebellum of Autistic Brain and Alters Neural Cell Adhesion, Migration and Synaptic Formation
Although the cellular mechanisms responsible for the pathogenesis of autism are not understood, a growing number of studies have suggested that localized inflammation of the...
Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors
Abnormal immune responses have been reported to be associated with autism. A number of studies showed that cytokines were increased in the blood, brain, and...
Gestational Exposure to a Viral Mimetic Poly(I-C) Results in Long-Lasting Changes in Mitochondrial Function by Leucocytes in the Adult Offspring
Maternal immune activation (MIA) is a potential risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ). The present study reports for the first time...