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Biopersistence and brain translocation of aluminum adjuvants of vaccines

Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following...
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In vivo absorption of aluminium-containing vaccine adjuvants using 26Al

Aluminium hydroxide (AH) and aluminium phosphate (AP) adjuvants, labelled with 26Al, were injected intramuscularly (i.m.) in New Zealand White rabbits.... This study has demonstrated that...
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Aluminum toxicokinetics regarding infant diet and vaccination

Some vaccines contain aluminum adjuvants to enhance the immunological response, and it has been postulated that this aluminum could contribute to adverse health effects, especially...
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Updated aluminum pharmacokinetics following infant exposures through diet and vaccination

Aluminum is a ubiquitous element that is released naturally into the environment via volcanic activity and the breakdown of rocks on the earth's surface. Exposure...
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The interrelationship between silicon and aluminium in the biological effects of aluminium

It is well established that aluminium is toxic at the cellular level and that pathological symptoms follow its entry into organisms (plants, fish, humans) when...
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Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line

Aluminium-based adjuvants (ABA) are the predominant adjuvants used in human vaccinations. While a consensus is yet to be reached on the aetiology of the biological...
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Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle

Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular...
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Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of...
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Silicon reduces aluminum accumulation in rats Relevance to the aluminum hypothesis of Alzheimer disease

In recent years, a possible relation between the aluminum and silicon levels in drinking water and the risk of Alzheimer disease (AD) has been established.......
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