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The proinflammatory effect of C-reactive protein on human endothelial cells depends on the Fc?RIIa genotype.
CRP-stimulated expression of ICAM-1 and E-selectin was dependent on the specific FcγRIIa-genotype, with most pronounced induction in HUVEC with the FcγRIIa-R/R genotype, followed by H/R...
Immune mediators in the brain and peripheral tissues in autism spectrum disorder.
Increasing evidence points to a central role for immune dysregulation in autism spectrum disorder (ASD).... The findings indicate that the immune system is a point...
Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice.
Maternal immune activation (MIA) results in the development of autism in the offspring via hyperactivation of IL-6 signaling.... We conclude that complex and not necessarily...
Preliminary evidence of neuropathology in nonhuman primates prenatally exposed to maternal immune activation.
Brain, behavior, and immunity 2015; 48():139-46 Maternal infection during pregnancy increases the risk for neurodevelopmental disorders in offspring.... The data provide the first evidence that...
Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model.
Prenatal exposure to maternal immune activation (MIA) increases the risk of schizophrenia and autism in the offspring.... The main findings were: (i) Adult MIA-exposed mice...
Maternal Lipopolysaccharide Exposure Promotes Immunological Functional Changes in Adult Offspring CD4+ T Cells.
Maternal immune activation (MIA) is a risk factor for autism and schizophrenia. However, how MIA affects offspring immune function remains unknown.... Our results showed that...
What is the role of vitamin D in autism?
A growing body of literature suggests that higher serum 25-hydroxyvitamin D [25(OH)D] concentrations, either in utero or in early life, may reduce the risk of...
Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities
People with neurodevelopmental disorders and intellectual disabilities have much greater health care needs. The Vitamin D Task Force of the American Academy of Developmental Medicine...
Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring
Experimentally activating the maternal immune system during pregnancy in rodents produces offspring with abnormal brain and behavioral development.... Results extended the findings in rodent MIA...