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Serum and CSF levels of cytokines in acute encephalopathy following prolonged febrile seizures.
It is well known that an acute encephalopathy occasionally follows prolonged febrile seizures. We measured the concentrations of interferon-gamma, tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2),...
Risk of febrile seizures after first dose of measles-mumps-rubella-varicella vaccine: a population-based cohort study.
The combination measles-mumps-rubella-varicella (MMRV) vaccine currently used in Canada (Priorix-Tetra) may increase the risk of febrile seizures relative to the separate vaccines (MMR and varicella)...
Adverse events following 12 and 18 month vaccinations: a population-based, self-controlled case series analysis.
Live vaccines have distinct safety profiles, potentially causing systemic reactions one to 2 weeks after administration.... Future studies should examine whether these events could be...
Vaccines and Febrile Seizures
Vaccine administration is the second leading cause of febrile seizures (FS).... This review discusses the clinical implications of FS, its potential link to vaccinations and...
Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism
Th1-like (IL-2, IFN-gamma) and Th2-like (IL-4, IL-6, and IL-10) cytokines were examined in CD4+ and CD8+ T cells in children with autism.... These data suggest...
Preliminary evidence of neuropathology in nonhuman primates prenatally exposed to maternal immune activation.
Maternal infection during pregnancy increases the risk for neurodevelopmental disorders in offspring. Rodent models have played a critical role in establishing maternal immune activation (MIA)...
Neonatal vaccination with bacillus Calmette-Guérin and hepatitis B vaccines modulates hippocampal synaptic plasticity in rats.
Immune activation can exert multiple effects on synaptic transmission. Our study demonstrates the influence of neonatal vaccination on hippocampal synaptic plasticity in rats under normal...
The Basics of Brain Development
Over the past several decades, significant advances have been made in our understanding of the basic stages and mechanisms of mammalian brain development. Studies elucidating...
Brain Development in Rodents and Humans: Identifying Benchmarks of Maturation and Vulnerability to Injury Across Species
Hypoxic-ischemic and traumatic brain injuries are leading causes of long-term mortality and disability in infants and children.... We consider the timing of neurogenesis, synaptogenesis, gliogenesis,...
Autism Spectrum Disorder Secondary to Enterovirus Encephalitis
We describe a 32-month-old patient with enteroviral encephalitis confirmed by polymerase chain reaction in cerebrospinal fluid, with unfavorable clinical course with marked developmental regression, autistic...