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Austistic Symptoms Following Herpes Encephalitis
Autism is a childhood onset neurodevelopmental disorder characterized by reciprocal social deficits, communication impairment, and rigid ritualistic interests, with the onset almost always before three...
Onset at age 14 of a typical autistic syndrome A case report
Journal of autism and developmental disorders 1986; 16(3):369-75 No abstract available
Autistic disorder and viral infections
One proposed etiology for autism is viral infection very early in development.... Many studies over the years have presented evidence both for and against the...
Acquired reversible autistic syndrome in acute encephalopathic illness in children
In seeking the neurologic substrate of the autistic syndrome of childhood, previous studies have implicated the medial temporal lobe or the ring of mesolimbic cortex...
Early effects of lipopolysaccharide- induced inflammation on foetal brain development in rat
Studies in humans and animal models link maternal infection and imbalanced levels of inflammatory mediators in the foetal brain to the aetiology of neuropsychiatric disorders.......
Maternal immune activation by LPS selectively alters specific gene expression profiles
Maternal immune activation (MIA) is a risk factor for the development of schizophrenia and autism. Infections during pregnancy activate the mother's immune system and alter...
Regional differences in synaptogenesis in human cerebral cortex
The formation of synaptic contacts in human cerebral cortex was compared in two cortical regions: auditory cortex (Heschl's gyrus) and prefrontal cortex (middle frontal gyrus).......
Metabolic consequences of interleukin 6 challenge in developing neurons and astroglia
Maternal immune activation and subsequent interleukin-6 (IL-6) induction disrupt normal brain development and predispose the offspring to developing autism and schizophrenia.... Our findings are potentially...
Long-term pathological consequences of prenatal infection: beyond brain disorders.
Prenatal immunological adversities such as maternal infection have been widely acknowledged to contribute to an increased risk of neurodevelopmental brain disorders.... Targeting peripheral abnormalities may...
Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders.
Both genetic and environmental factors are thought to contribute to neurodevelopmental and neuropsychiatric disorders with maternal immune activation (MIA) being a risk factor for both...